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Recipes for your next scientific decision

Explore how you can connect biological evidence across studies to investigate candidates, compare indications and plan your next experiments. Start with the question you need to answer and build a rationale you can inspect and revisit.

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Start with your scientific question

The shared method for evaluating evidence

The Evidence Convergence Protocol gives you a four-stage structure for defining your question, bringing evidence together, evaluating it against your criteria and documenting what it supports or leaves unresolved.

Keep supporting and conflicting findings visible as you work toward your next scientific decision.

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Choose how to get started

Use the platform

If your scientific question and data foundation are ready, and you have platform access, use the knowing01 platform to explore the evidence and run your analyses.

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Get support

If you need help with your data foundation, analysis or scientific strategy, talk to our experts. We can run the work for you or contribute the part you need, such as preparing a data foundation.

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Built to evolve with your program

Your data foundation remains useful beyond the first question. Add new studies and internal findings, revisit your analyses and update the rationale as your evidence and program priorities change.

Reuse relevant evidence for related targets, indications or experiments when its scope fits. Extend the foundation where a new question needs different data, keeping the sources and context accessible to your team.

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What makes the evidence difficult to evaluate?

Findings spread across sources

You may have relevant findings in public studies, internal datasets and separate analyses. Bringing them into a shared context helps you see what each contributes to your question.

Different identifiers and biological settings

The same gene or protein can appear under different identifiers, while evidence from different tissues, species or study designs needs careful interpretation. You need to understand what can be compared and where the context differs.

Conflicting findings and evidence gaps

A signal in one study may be absent or reversed in another. You need to distinguish contradictory findings from missing coverage and assess them against the criteria that matter for your question.

A rationale that needs to evolve

New findings and changing program priorities can alter your interpretation. Keep the evidence and reasoning behind your conclusions accessible so you can revisit them as your question develops.

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