As modular SaaS in the cloud, knowing01 is adaptable to your team needs and budget.
Link your data sets with Explore and discover patterns. Subscribing to this core module, you search, link and compare your analysis results with one click at unprecedented speed no matter the bio data type. Consider all available data relevant to your hypothesis.
We offer one product for all your data types.
Independent of organisms (human, mouse, pig, plant, fly, worm, bacteria, fungi, …), we cover a continuously expanding range of data domains, which we call bio data types. In case your specific needs aren’t covered yet, we’d love to hear from you!
- GWAS summary statistics
- Differentially regulated genes
- Methylated regions
- Deregulated metabolites
- Phosphorylation sites
- Transcription factor targets
- Deregulated microRNAs
- many many more
Explore beta user flow
Simply sign-up for an account, and start uploading data sets to your dedicated knowing01 cloud space. Your data sets are kept in the original format and are only accessible by you – unless of course you decide to share them with your team members.
Across all data sets available to you – whether its your own, shared by a colleague or from the public domain – you link the data with one mouse-click and start exploring for patterns along your current hypothesis or discover new ones. Or simply find your key marker in all your data.
Take the next step
The results are shown immediately in our web-interface. Stored in your protected area, results can be shared with colleagues or downloaded. Transparency is at our core here: Each result includes the path taken to connect your data sets, ensuring reproducibility.
Example use cases
Differentially regulated genes (DEGs)
You received ten different comparisons of combinations after bulk RNAseq measurements and analysis from your NGS measurement facility. The sets cover different genetic background, time-points at two tumor stages (mid and severe). Now, which genes are exclusively regulated between time points irrespective of tumor stage? What differences between tumor stages are not affected by time? Are these genes targeted by the major transcription factor previously described to modulate the disease?
How Explore can help
Use Explore to combine the ten sets in a few clicks according to the relevancy for your questions and get the TF target gene list.
Be done in a day and use tomorrow to plan your validation experiments with the unique genes!
Translating between mouse and human
You have results comparing tissue gene expression from a k.o. mouse model exhibiting e.g. impaired lung function to control mice. Now you need to compare your results to regulated genes obtained from a human cohort at your local clinic and a public dataset, e.g. from TGCA?
How Explore can help
Use Explore to combine results of murine genes and human genes. Work with all data sets in the format you know. See common regulation on mouse-gene/human genes.
Be done and in a day and use tomorrow to plan you next experiments to validate your mouse gene top hits that are prioritized by having a set of top genes of early cancer signals in your k.o. mouse model.
Common genomic loci from GWAS
You have performed a new GWAS in a large cohort associating immune modulating marker with genetic variation. Now you instantly want to know, wich nominal loci are also picked up as the genome-wide significant loci of five human diseases that associate with impaired immune response?
How Explore can help
Use Explore to combine your new results (the GWAS summary statistics) with each disease GWAS separately and combined. See all common significant loci, that are identified including a proxy search of high linkage disequilibrium. Be done and in a day, used the results to enrich your manuscript and show relevance of your approach.
Upcoming modules on our roadmap
Characterize (coming soon)
Characterize lets you dive into the biological meaning of your data sets. Get an instant overview of the knowns, enrichments and unkowns from your list of genes, proteins, variants, mutations and more.
A.I. extensions (coming 2021)
A.I. extensions that can be flexibly added on top of the Characterize or Explore modules, harness the power of new technology to supercharge your data driven insight generation. Do you need help understanding enrichment analysis? Do you want to know if your analysis results are meaningful? Do you have questions about the quality of your data? Do you want to identify new hypothesis in an unbiased manner? Do you want to learn about comorbidity?